PROBLEM TO BE SOLVED: To provide a novel active ingredient which can be blended in a skin external preparation and is useful as a skin external preparation for improving rough skin, antipruritic, analgesic or sensitive skin. SOLUTION: (A) A hydrolyzate solution obtained by treating an extract solution of rice with a protease, and (B) a hydrolyzate solution obtained by treating an extract solution of rice bran with a protease. An inhibitor of nerve growth factor production, which comprises a mixed solution of and as an active ingredient. [Selection diagram] Figure 1【課題】皮膚外用剤に配合可能であり、肌荒れ改善用、鎮痒用、鎮痛用又は敏感肌用の皮膚外用剤に有用な新規有効成分の提供。【解決手段】（Ａ）米の抽出物溶液を蛋白分解酵素で処理して得られる加水分解物溶液と、（Ｂ）米糠の抽出物溶液を蛋白分解酵素で処理して得られる加水分解物溶液との混合物溶液を有効成分とする神経成長因子生成抑制剤。【選択図】図１
