Universite Claude Bernard Lyon 1;Centre National de la Recherche Scientifique (CNRS);Institut National de la Sante et de la Recherche Medicale (INSERM);Sorbonne Universite
发明人:
Marie-Thérèse Dimanche-Boitrel,Stéphane Bach,Claire Delehouze,Peter Goekjian,Arnaud Comte
申请号：
US15768395
公开号：
US10457678B2
申请日:
2016.10.13
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention relates to new N1- and N7-substituted sibiriline derivatives of the following general formula (I): (I) or a pharmaceutically acceptable salt and/or solvate thereof, notably for use as drug, in particular for use as inhibitor of cellular necroptosis. The present invention also relates to a pharmaceutical composition comprising such a compound and processes to prepare such a compound. The present invention also encompasses the use of a compound of the general formula (I) for organs preservation.
