A vital sign monitoring system using an optical sensor is provided. The vital sign monitoring system, and related methods and devices described herein, is equipped with a camera or other optical sensor to remotely detect and measure one or more physiological parameters (e.g., vital signs) of a subject. For example, the vital sign monitoring system can detect, measure, and/or monitor heart rates and respiration rates from one or multiple subjects simultaneously using advanced signal processing techniques, including adaptive color beamforming to more accurately detect and measure the vital sign(s) of interest.