Elena Barbanti;Laura Faravelli;Patricia Salvati;Renato Canevotti;Francesco Ponzini
发明人:
Elena Barbanti,Laura Faravelli,Patricia Salvati,Renato Canevotti,Francesco Ponzini
申请号：
US12747008
公开号：
US08530701B2
申请日:
2008.12.01
申请国别(地区):
US
年份:
2013
代理人:
摘要：
A process for obtaining therapeutically active 2-[4-(3- and 2-(fluorobenzyloxy)benzylamino]-propanamides and their salts with pharmaceutically acceptable acids with a high degree of purity, i.e. with a content of dibenzyl derivatives impurities lower than 0.03% by weight. The process is carried out by submitting a Schiff base intermediate to a reduction reaction with a reducing agent in an amount of organic solvent to allow the formation (and presence during a substantial portion of the reduction reaction) of a suspension of the Schiff base.
