Katherine Eleanor Crosby;Qingfu Zeng;Roberto Polakiewicz;Klarisa Rikova;Ailan Guo;Kimberly A Lee
发明人:
Klarisa Rikova,Roberto Polakiewicz,Ailan Guo,Katherine Eleanor Crosby,Qingfu Zeng,Kimberly A Lee
申请号：
US12982490
公开号：
US08466160B2
申请日:
2010.12.30
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The invention discloses a previously unidentified subset of mammalian non-small cell lung carcinomas (NSCLC) in which platelet-derived growth factor receptor alpha (PDGFRα) is expressed and is driving the disease, and provides methods for identifying a mammalian NSCLC tumor that belongs to a subset of NSCLC tumors in which PDGFRα is expressed, and for identifying a NSCLC tumor that is likely to respond to a PDGFRα-inhibiting therapeutic. The invention also provides methods for inhibiting the progression of a mammalian NSCLC tumor in which PDGFRα is expressed, and for determining whether a compound inhibits the progression of a PDGFRα-expressing mammalian NSCLC tumor.
