DERIVÉS DE COMPOSÉS À BASE DE SULTONES SUBSTITUÉS PAR DES NUCLÉOPHILES, NOTAMMENT DES RADIONUCLÉIDES, ET LEUR UTILISATION POUR LE MARQUAGE DE MACROMOLECULES
The invention relates to polysultone derivatives used as precursors to radiolabelled macromolecules usable for medicine and in nuclear imaging. The aim of the invention is to provide novel prosthetic compounds or groupings, the synthesis of which is straightforward, easy and automatable, enabling access to economical and effective radiolabelled macromolecules. The aim is achieved by the invention, which involves compounds of formula 10 or 11. Said double-sultone derivatives are produced by opening the sultone rings using a nucleophile radical Ri which may be a radionucleide R* for one of the sultone rings and an active radical peptide Ra for the other sultone ring. The invention also relates to the method for producing the abovementioned compounds, as well as to the drugs or diagnosis products that the latter are capable of forming.
