Hydrodynamic diameter (hydrodynamic diameter D h) is an 8 to 100 nm, including a center portion and a peripheral portion, and the calculated diameter of the central part (D c) is from 6 to 90 nm, of the periphery estimated thickness (T p) shall be a D h = D c + 2T p, the center is (i) more than 30% monomer residues, based on the number of the cross-linked by being cross-containing monomer residues that form the crosslinked polymeric framework (framework) less than 30% of the combined polymer framework and / or (ii) minutes, the number of points the number of monomer residues, and comprises a branched polymer framework that comprises monomer residues, wherein the center of one or more 4 or more of the chelating group comprise a chelating or more to allow chelating of the multi-charged cation and the chelating group consisting of -COOR 1, -P = O (OR 1) (OR 2), and -S (= O) 2 OR 1 are independently selected from the group, R 1 and R 2 is a negative charge, H, and it is independently selected from the group consisting of lower alkyl, wherein the peripheral portion comprises a synthetic polymeric material attached to the center covalently, synthetic polymeric material bio-inert and a hydrophilic, electrically neutral or a zwitterionic adult spherical nanostructures (globular nanostructure) is disclosed herein. In addition, such nanoparticles, and optionally also is disclosed kit and methods of obtaining such a composition comprising a purpose, such compositions of the composition, such a composition comprising a radionuclide.유체역학적 직경(hydrodynamic diameter Dh)이 8 내지 100 nm이며, 중심부 및 주변부를 포함하고, 상기 중심부의 계산된 직경 (Dc)은 6 내지 90 nm이며, 상기 주변부의 추정 두께 (Tp)는 Dh=Dc+2Tp가 되도록 하며, 상기 중심부는 (i) 개수를 기준으로 30% 이상의 단량체 잔기가 가교결합됨으로써 가교결합된 중합체 프레임워크 (framework)를 형성하는 단량체 잔기를 포함하는 가교결합된 중합체 프레임워크 및/또는 (ii) 분지점의 수가 단량체 잔기의 수의 30% 이상인, 단량체 잔기를 포함하는 분지형 중합체 프레임워크를 포함하고, 상기 중심부는 킬레이팅 기 중 4개 이상이 하나 이상의 다중 하전된 양이온의 킬레이팅을 허용하는 킬레이팅 기를 포함하며, 상기 킬레이팅 기는 -COOR1, -P=O(OR1)(OR2), 및 -S(=O)2OR1로 이루어진 군으로부터 독립
