SALITURO, FRANCESCO G.,ROBICHAUD, ALBERT JEAN,WATSON, PAUL,HUNKE, WILLIAM
申请号：
CA2988262
公开号：
CA2988262A1
申请日:
2016.06.17
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
Provided herein are pharmaceutically acceptable aqueous solution comprising a neuroactive steroid, a sulfobutyl ether beta cyclodextrin and a buffer； wherein: the solution is a stable solution between a pH of about 3 and about 9, e.g., at room temperature, for at least 1, 2, 3, 4 weeks； 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 months； 1, 2, 3 years or more； the buffer is present at a concentration of at least 0.1 mM； or the solution remains substantially free of impurities (e.g., the solution is substantially free of impurities at room temperature for at least 1, 2, 3, 4 weeks； 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 months； 1, 2, 3 years or more).
