Bernard T. Golding;Robert G. Tyson;Rhys Whomsley;Richard Franklin
发明人:
Richard Franklin,Robert G. Tyson,Bernard T. Golding,Rhys Whomsley
申请号：
US13496316
公开号：
US20120178666A1
申请日:
2010.09.15
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Prodrugs of guanfacine with amino acids or short peptides, pharmaceutical compositions containing such prodrugs and a method for providing therapeutic benefit in the treatment of ADHD/ODD (attention deficient hyperactivity disorder and oppositional defiance disorder) with guanfacine prodrugs are provided herein. Additionally, methods for minimizing or avoiding the adverse gastrointestinal side effects associated with guanfacine administration, as well as improving the pharmacokinetics of guanfacine are provided herein.
