The present invention provides an alkaloid fraction of Bhodophiala Bifida (Herb.) Traub for use in the treatment or prevention of inflammation, rheumatoid arthritis, ulcerative colitis, sepsis, acute pulmonary disease, inflammatory infections, such as inflammatory and/or fibrotic lung and/or kidney diseases, osteoporosis, Castlemans disease, psoriatic arthritis, juvenile rheumatoid arthritis or further non-specific inflammatory joint diseases.