Anthony Costello;Christopher Hovens;Niall Corcoran
发明人:
Christopher Hovens,Niall Corcoran,Anthony Costello
申请号：
US13584263
公开号：
US20130064821A1
申请日:
2012.08.13
申请国别(地区):
US
年份:
2013
代理人:
摘要：
A polypeptide comprising an androgen binding region, the androgen binding region capable of binding to an androgen at a sufficient affinity or avidity such that upon administration of the polypeptide to a mammalian subject the level of biologically available androgen is decreased. Specifically disclosed is an AR IgG1 Fc fusion protein, comprising the androgen binding domain of human androgen receptor and the Fc region of IgG. This fusion protein is used in the treatment of prostate cancer and testosterone flare.
