창원대학교 산학협력단;CHANGWON NATIONAL UNIVERSITY INDUSTRY UNIVERSITY COOPERATION FOUNDATION
发明人:
LEE, Yong Ill,이용일,MIRKOMIL, Sharipov,샤리포브미르코밀
申请号：
KRKR2018/004254
公开号：
WO2018/190639A1
申请日:
2018.04.11
申请国别(地区):
KR
年份:
2018
代理人:
摘要：
The present invention relates to nanocarriers for prostate cancer cell targeted therapy and/or diagnosis thereof, characterized by micelles comprising a phosphate surfactant represented by a specific chemical formula. The micelles comprising the phosphate surfactant constituting the nanocarriers for prostate cancer cell targeted therapy and/or diagnosis thereof, according to the present invention, enables selective release, into prostate cancer cells, of therapeutic agent or diagnostic agent particles, which have been cleaved by overexpressed enzymes near the prostate cancer cells and loaded into the micelles, thereby enabling therapeutic and/or diagnostic effects to be maximized while more remarkably reducing the side effects of drugs in vivo than conventional technology.La présente invention concerne des nanovecteurs pour thérapie ciblée des cellules du cancer de la prostate et/ou son diagnostic, caractérisés par des micelles comprenant un tensioactif phosphate représenté par une formule chimique spécifique. Les micelles comprenant le tensioactif phosphate constituant les nanovecteurs pour la thérapie ciblée des cellules du cancer de la prostate et/ou son diagnostic selon la présente invention permettent la libération sélective, dans les cellules du cancer de la prostate, de particules d'agents thérapeutiques ou diagnostiques, qui ont été clivées par des enzymes surexprimées à proximité des cellules du cancer de la prostate et chargées dans les micelles, pour maximiser ainsi leurs effets thérapeutiques et/ou diagnostiques tout en réduisant de manière plus considérable les effets secondaires des médicaments in vivo que la technologie classique.본 발명은 특정 화학식으로 표시되는 인산염(phosphate) 계면활성제로 이루어진 미셀(micelle)인 것을 특징으로 하는 전립선암 세포 표적 치료 및/또는 진단용 나노담체에 대한 것으로서, 본 발명에 따른 전립선암 세포 표적 치료 및/또는 진단용 나노담체를 구성하는 인산염 계면활성제로 이루어진 미셀은, 전립선암 세포 주변의 과발현된 효소에 의해 절단되어 미셀에 로딩된 치료제 또는 진단제 입자를 전립선암 세포에 선택적으로 방출하는 것이 가능하기 때문에 종래 기술에 비해 생체 내에서 약물 부작용을 현저히 감소시키면서도 치료 및/또는 진단 효과를 극대화할 수 있다.
