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Article of manufacture comprising aflibercept or 2IV aflibercept
专利权人:
SANOFI
发明人:
REMI CASTAN,SYLVIE ASSADOURIAN,EMMANUELLE MAGHERINI
申请号:
ARP130102744
公开号:
AR091967A1
申请日:
2013.08.02
申请国别(地区):
AR
年份:
2015
代理人:
摘要:
Requirement 1: include (a) packaging materials, (b) polymerized peptide of No. 1 SEQ or biocide of No. 1 SEQ and (c) labels or instructions in No. 1 SEQ package, including labels, to explain to potential users: polymerized peptide or its biocide, Patients with severe bleeding should not be treated, the treatment of patients with gastrointestinal perforation should be stopped, and / or the treatment should be stopped for patients with severe trauma. Requirement 10: a method to promote the use of SEQ ID 1 polypeptide,Or a biological agent, including a method, at least at the stage of transmitting a specific group information in a container, the group information includes: (a) polypeptide or its biological agent should not be given to patients with severe bleeding; and (or) (b) polypeptide or its biological agent should be stopped at the time of patient trial. Gastrointestinal perforation and / or (c) polypeptides or their biological agents must be stopped in patients with damage. Requirement 11: treatment of cancer or cancer symptoms in patients in needUnderstand that this method is effective for the treatment of patients, and the dosage is equivalent to a polypeptide of SEQ ID 1, or a biological agent of this polypeptide. In this case, (a) polypeptide should not be applied to patients with severe bleeding, or the polypeptide should be bioassayed, and (b) polypeptide should be applied, or the polypeptide should be bioassayed, Treatment of patients with gastrointestinal perforation should be discontinued, and / or (c) polypeptides or bioassays of patients with severe injury should be discontinued. Requirement 12: method of treatment for colorectal cancer (CRC) in patients who need to treat symptoms of colorectal cancer or colorectal cancer,This method includes effective treatment of patients from a polypeptide of SEQ ID 1, or from biopharmaceuticals of SEQ ID 1, folic acid, 5-fluoro (5-FU) and irinotecan, in which: (a) polypeptide or its biopharmaceuticals should not b
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