CASSETTES OPTIMISÉES D'EXPRESSION GÉNÉTIQUE DU FACTEUR VIII DE COAGULATION HUMAIN ET LEUR UTILISATION

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专利权人:

The University of North Carolina at Chapel Hill

发明人:

XIAO, Xiao,LI, Juan,YUAN, Zhenhua

申请号：

EP16747334

公开号：

EP3253786A4

申请日:

2016.02.05

申请国别(地区):

EP

年份:

2018

代理人:

摘要：

The invention relates to synthetic liver-specific promoters and expression constructs for producing polypeptides and functional nucleic acids in the liver of a subject. The invention further relates to Factor VIII proteins containing modifications in the amino acid sequence of the Factor VIII protein, as well as nucleic acid constructs encoding the Factor VIII proteins and methods of using these compositions to treat a bleeding disorder.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/