This invention relates to novel substituted estratrien derivatives of generalformula (I) useful in therapy, especially for use in the treatment and/or preventionof a steroid hormone dependent disorder requiring the inhibition of a 17β-hydroxysteroiddehydrogenase (17- HSD) type 1, type 2 and/or type 3 enzyme, as well as to theirsalts, to pharmaceutical preparations containing these compounds and to processesfor the preparation of these compounds.