- 2--5-5-2-5--26--1236--4--2- Pharmaceutical composition for preventing or treating Prion disease containing E-methyl 2-chloro-5-5-2-5-nitro-26-dioxo-1236-tetrahydropyrimidin-4-ylvinylfuran-2-ylbenzoate or pharmaceutically acceptable salts thereof as an active ingredient
KOREA CENTER FOR DISEASE CONTROL AND PREVENTION;대한민국(관리부서 질병관리본부장);BIOINFORMATICS & MOLECULAR DESIGN RESEARCH CENTER;사단법인 분자설계연구소
发明人:
NO KYOUNG TAI,노경태,CHOI JIWON,최지원,RAJIV GANDHI GOVINDARAJ,라즈브 간디 고빈다라즈,JOUNG JONG YOUNG,정종영,LEE YEONG SEON,이영선,LEE JEONGMIN,이정민,HYEON JAE WOOK,현재욱,JU YOUNG RAN,주영란,KIM SU YEON,김수연
申请号：
KR1020180001334
公开号：
KR1020190083548A
申请日:
2018.01.04
申请国别(地区):
KR
年份:
2019
代理人:
摘要：
The present invention relates to a pharmaceutical composition for preventing or treating prion disease, comprising the compound of (E)-methyl 2-chloro-5-(5-(2-(5-nitro-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)vinyl)furan-2-yl)benzoate or a pharmaceutically acceptable salt thereof as an active ingredient. The compound inhibits aggregate formation of prion proteins in a concentration-dependent manner, has no cytotoxicity, and suppresses the expression of transformed prions in cells expressing transformed prions, and thus may be beneficially used as the active ingredient of a composition for preventing or treating prion disease.본 발명은 (이)-메틸 2-클로로-5-(5-(2-(5-니트로-2,6-다이옥소-1,2,3,6-테트라하이드로피리미딘-4-일)비닐)푸란-2-일)벤조에이트 [(E)-methyl 2-chloro-5-(5-(2-(5-nitro-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)vinyl)furan-2-yl)benzoate] 화합물 또는 이의 약학적으로 허용가능한 염을 유효성분으로 포함하는 프리온(Prion) 질환 예방 또는 치료용 약학적 조성물에 관한 것으로, 상기 화합물은 프리온 단백질의 침반 형성을 농도의존적으로 억제하고, 세포독성이 없으며, 변형 프리온을 발현하는 세포에서 변형 프리온의 발현을 억제하므로 프리온 질환 예방 또는 치료용 조성물의 유효성분으로 유용하게 사용될 수 있다.
