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VECTEURS VIRAUX DESTINES AU TRAITEMENT DU DIABETE
专利权人:
UNIVERSITAT AUTONOMA DE BARCELONA
发明人:
MALLOL DOMINGUEZ, CRISTINA,BOSCH TUBERT, FATIMA,JIMENEZ CENZANO, VERONICA
申请号:
CA2969599
公开号:
CA2969599A1
申请日:
2015.12.07
申请国别(地区):
CA
年份:
2016
代理人:
摘要:
They are provided gene constructs comprising a nucleotide sequence encoding the Insulin-like growth factor 1 (IGF-1) of a mammal; and target sequences of a microRNA of a tissue where the expression of IGF-1 is wanted to be prevented, wherein the sequences (a) and (b) are operationally linked to a promoter of ubiquitous expression. Also provided are expression vectors comprising the gene construct and pharmaceutical compositions comprising them. They are useful in the treatment and/or prevention of diabetes mellitus in mammals, wherein a dysfunction and/or a loss of the beta-cells of the islets of Langerhans is present.
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