Disclosed is a long-term effective patch structure including a binding layer, an absorbing layer and a water-proof layer sequentially stacked together. The binding layer has a function of attaching and fixing, and is configured to be attached and fixed on a skin. Sweat or liquid from the skin can pass through the binding layer to reach the absorbing layer, which is aligned with binding layer at the edge. The water-proof layer is water-proof and has vapor permeability, and its area is larger than the area of the absorbing layer. The outer part of the water-proof layer is attachable to the skin. Since the absorbing layer can absorb the liquid from the skin and the water-proof layer can ventilate the vapor to the outside, the skin is kept dry and comfortable and suitable to be attached to human skin for a long period of time without inducing skin allergy or any discomfort. The present invention can also works with medical devices or wearing devices for continuous and long term operation so as to maintain preset medical function.本發明係一種長效型貼片敷料結構,包括依序堆疊的貼附層、吸水層以及防水層,其中貼附層具有貼附及固定效果,可直接貼附並固定於皮膚,並使皮膚上的液體穿透而到達吸水層,而吸水層吸收液體並切齊貼附層,且防水層具防水性及高水蒸氣通透性,其面積是大於吸水層的面積,而外側部分可直接貼附於皮膚。由於吸水層可吸收皮膚上的液體,而防水層可使水蒸氣通透而排放至外部,所以能保持皮膚乾爽,適合長時間貼附於人體表面,避免皮膚過敏或紅腫的不適感或刺激感,並可與需長天數連續運作的醫療裝置或穿戴裝置配合使用,維持預設的醫療功能。