Ryan Delaney,Matthew James Southard,Adrian C. Samaniego,Kenneth Blood,Marina Katelyn Bull,Reginald Stilwell,Carolyn Barrett Rorick,Matthew Peterson,Jan Zajdowicz,Arthur Joslyn,Kathryn Hanzlicek
申请号：
US15995320
公开号：
US20180280575A1
申请日:
2018.06.01
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Provided are systems and methods for treating or processing tissue, and tissue products made using such systems and methods. Also provided are ball mill processing devices and systems useful for processing materials such as tissue. The methods involve combining tissue with or without a processing solution in a processing vessel and applying resonant acoustic energy thereto. The resonant acoustic energy rapidly agitates the tissue with the processing solution by vibration, thereby improving the rate and/or efficiency of processing. The general method provided is broadly applicable to a variety of tissue processing methods, the processing solution and features of the resonant acoustic energy being selected based on the type of tissue to be processed and the nature of the processing to be performed. Exemplary methods include methods of bone demineralization, tissue decellularization, tissue cryopreservation, production of stromal vascular fraction, tissue fragmentation, tissue cleansing, and tissue decontamination, and assessment of microbial load.
