BASHKIN JAMES K.,EDWARDS TERRI G.,FISHER CHRISTOPHER,HARRIS JR. GEORGE D,KOELLER KEVIN J.
申请号：
NZ62329212
公开号：
NZ623292A
申请日:
2012.10.10
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
The disclosure relates to guanidinyl-substituted polyamides of the abstract figure, wherein m is 5-12 n is 4-10 G is a guanidinyl radical each X is independently selected from 4-amino-2-carbonyl-N-methylimidazole, 4-amino-2-carbonyl-N-methylpyrrole or 6-alanine gammaq is g-aminobutyric acid, 2,4-diaminobutyric acid or H2N(CH2)2CH(NHC(=O)NHR)CO2H, wherein R is -(CH2)3-N(CH3)-(CH2)3-NH2 or -(CH2)3-N(CH3)2 and A is 3,3&rsquo-diamino-N-methyldipropylamine or 3-(dimethylamino)propylamine. The disclosure also relates to their use for binding double-stranded DNA in a sequence-specific manner and treating cancer and an infection is caused by HPV, Epstein-Barr viruses, herpes viruses, adenoviruses, BK and pox viruses.
