PROCESS FOR PREPARING AN ANTI-CANCER AGENT, 1-((4-(4-FLUORO-2-METHYL-1H- INDOL-5-YLOXY)-6-METHOXYQUINOLIN-7-YLOXY)METHYL) CYCLOPROPANAMINE, ITS CRYSTALLINE FORM AND ITS SALTS

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专利权人:

发明人:

CHEN GUOQING PAUL

申请号：

IN201717043008

公开号：

IN201717043008A

申请日:

2017.11.30

申请国别(地区):

IN

年份:

2018

代理人:

摘要：

The present invention relates a new process to synthesize 1-((4-(4-Fluoro-2-methyl-1H- indol-5-yloxy)-6-methoxyquinolin-7- yloxy)methyl)cyclopropanamine (AL3818). A stable crystalline form of A13818 has been prepared. Salts and their crystalline forms of AL3818 have been also prepared. Anti-cancer and optometric activities of AL3818 and its salts have been further tested. New process has been outlined in Scheme I.

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中国工程科技知识中心

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