Methods and compositions for targeting macromolecules into the nucleus

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专利权人:

Yuh Min Chook

发明人:

Yuh Min Chook

申请号：

US11697656

公开号：

US08470976B2

申请日:

2007.04.06

申请国别(地区):

US

年份:

2013

代理人:

摘要：

The present invention includes compositions, methods and kits for directing an agent across the nuclear membrane of a cell. The present invention includes a Karyopherin beta2 translocation motif in a polypeptide having a slightly positively charged region or a slightly hydrophobic region and one or more R/K/H-X(2-5)-P-Y motifs. The polypeptide targets the agent into the cell nucleus.

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