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METHODS AND COMPOSITIONS FOR SILENCING GENE FAMILIES USING ARTIFICIAL MICRORNAS
专利权人:
Brian McGonigle
发明人:
Brian McGonigle
申请号:
US13462922
公开号:
US20120297508A1
申请日:
2012.05.03
申请国别(地区):
US
年份:
2012
代理人:
摘要:
Methods and compositions are provided which allow for a single microRNA (miRNA) to reduce the level of expression of at least two members of the same protein and/or gene family. Such methods and compositions employ miRNA expression constructs having a structure such that the most abundant form of miRNA produced from the construct is a 22-nucleotide miRNA. The 22-nucleotide miRNA produced from the miRNA expression construct thereby reduces the level of expression of not only the target sequence for the miRNA, but also reduces the level of expression of at least one additional sequence from the same protein and/or gene family as the target sequence.
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中国工程科技知识中心
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