ANDRIES, KOENRAAD J.L.M.,KOUL, ANIL,GUILLEMONT, JEROME E.G.,LANCOIS, DAVID F.A.,MOTTE, MAGALI M.S.,DORANGE, ISMET,BACKX, LEO J. J.
申请号：
HRP20120912
公开号：
HRP20120912T1
申请日:
2012.11.13
申请国别(地区):
HR
年份:
2012
代理人:
摘要：
Use of a compound for the manufacture of a medicament for the treatment of a bacterial infection provided that the bacterial infection is other than a Mycobacterial infection, said compound being a compound of formula (Ia) or (Ib) a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, a tautomeric form thereof or a N-oxide form thereof, wherein R1 is hydrogen, halo, haloalkyl, cyano, hydroxy, Ar, Het, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl； p is 1, 2, 3 or 4； R2 is hydrogen, hydroxy, mercapto, alkyloxy, alkyloxyalkyloxy, alkylthio, mono or di(alkyl)amino or a radical of formula； R3 is alkyl, Ar, Ar-alkyl, Het or Het-alkyl； q is 1, 2 or 3； R4 and R5 are hydrogen, alkyl or benzyl； or R4 and R5 together and including the N to which they are attached may form a ring； R6 is hydrogen, halo, haloalkyl, hydroxy, Ar, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkythioalkyl, Ar-alkyl or di(Ar)alkyl； or two vicinal R6 radicals may be taken together to form a bivalent radical of formula &mdash；CH&boxH；CH&mdash；CH&boxH；CH&mdash；； r is 1, 2, 3, 4 or 5； R7 is hydrogen, alkyl, Ar or Het； R8 is hydrogen or alkyl； R9 is oxo； or R8 and R9 together form the radical &mdash；CH&boxH；CH&mdash；N&boxH；.
