NANOPARTICLES FOR TARGETED GENE THERAPY AND METHODS OF USE THEREOF

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专利权人:

发明人:

Randy Goomer

申请号：

US15305641

公开号：

US20170042819A1

申请日:

2015.04.23

申请国别(地区):

US

年份:

2017

代理人:

摘要：

The present disclosure provides targeted, polymeric nanoparticles which facilitate the delivery of small interfering RNAs, miRNAs and shRNA expressing plasmid DNAs and include an aggregate of nucleic acids and polycationic polymer scaffolds. Methods of making and using such nanoparticles are provided as are methods of treating cancer, including Glioblastoma Multiforme, prostate cancer and melanoma using such nanoparticles.

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