BRAUN, Marie-Gabrielle,ELLIOTT, Richard,HANAN, Emily,HEALD, Robert Andrew,MACLEOD, Calum,STABEN, Steven T.
申请号:
LT16733600
公开号:
LT3317284T
申请日:
2016.07.01
申请国别(地区):
LT
年份:
2020
代理人:
摘要:
Described herein are benzoxazepin oxazolidinone compounds with phosphoinositide-3 kinase (PI3K) modulation activity or function having the Formula I structure:or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such PI3K modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon PI3K dysregulation.