PROBLEM TO BE SOLVED: To provide a compound exhibiting a powerful and lasting ocular tension reduction function on an occasion for treating glaucoma and unaccompanied by prospects of side effects for eyes.SOLUTION: Compounds expressed by the formula (I), salts, solvates, or prodrugs thereof are provided. The compounds are highly safe prophylactic and/or therapeutic agents having powerful and lasting ocular tension reduction functions and unaccompanied by side effects such as eye irritations (e.g., hyperemia, cornea turbidity, etc.), hydatoid protein gains etc.: (Ris COOR, etc.； Ris a halogen, hydroxyl group, etc.； Z is a divalent group； W is a hydroxyl group, etc.).【課題】緑内障の治療において、強力かつ持続的な眼圧下降作用を有し、更に眼に対する副作用の懸念のない化合物の提供。【解決手段】式（Ｉ）で表される化合物、その塩、溶媒和物、又はプロドラッグ。前記化合物は強力で持続的な眼圧下降作用を有し、眼刺激性（充血、角膜混濁等）、房水タンパク質上昇等の副作用がなく、安全性が高い予防及び／又は治療剤である。（Ｒ１はＣＯＯＲ２等；Ｒ５はハロゲン、水酸基等；Ｚは２価の基；Ｗは水酸基等。）【選択図】なし
