The invention relates to polypeptides comprising, as constituent A, at leastthree monomers of a member of the TNF ligand family and, as constituent B, atleast two peptide linkers that link the monomers of the member of the TNFligand family to one another. The invention also relates to the use of thesepolypeptides for treating diseases and for producing a medicament or avaccine. The invention also relates to methods for producing and isolatingthese polypeptides, to nucleic acids that code for these polypeptides, tovectors containing these nucleic acids, to host cells transfected with thesevectors, and to pharmaceutical compositions containing these inventiveobjects. Finally, the invention relates to methods for the extracorporealmanipulation, depletion and/or removal of components contained in body fluids,e.g. by means of apheresis.
