Methods and compositions for modulating and detecting WISP activity

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专利权人:

Inc.;Genentech

发明人:

Filvaroff, Ellen,Desnoyers, Luc

申请号：

AU2006236649

公开号：

AU2006236649B2

申请日:

2006.04.13

申请国别(地区):

AU

年份:

2012

代理人:

摘要：

Methods and compositions for use in modulating the activity(s) of WISP-1 polypeptide are provided. WISP-1 antagonists include anti-WISP-1 antibodies, WISP-1 immunoadhesins and WISP-1 variants (and fusion proteins thereof) which inhibit or neutralize induction or secretion of HAS2, HA, CD44 or RHAMM by native human WISP-1 polypeptide in at least one type of mammalian cell. The invention also provides methods for in vitro, in situ, and/or in vivo diagnosis and/or treatment of mammalian cells or pathological conditions associated with native WISP-1 polypeptides.

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