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誤用抵抗性製剤
专利权人:
シマ ラブス インク.
发明人:
ハビブ、ワリド,ハメド、イーハブ,ヒルマン、リサ,クラリング、キャリー,モー、デレック
申请号:
JP2009528313
公开号:
JP5357032B2
申请日:
2007.09.14
申请国别(地区):
JP
年份:
2013
代理人:
摘要:
A pharmaceutical composition may include a granulate which may include at least one active pharmaceutical ingredient susceptible to abuse by an individual mixed with at least two materials, a first material that is substantially water insoluble and at least partially alcohol soluble and a second material that is substantially alcohol insoluble and at least partially water soluble, wherein the active pharmaceutical ingredient and the two materials are granulated in the presence of water and alcohol. The composition may also include a coating on the granulate exhibiting crush resistance which may have a material that is deposited on the granulate using an alcohol based solvent. The composition further comprises a second particle comprising a fat/wax. The present invention also includes a coated granulate, various dosage forms of the composition, as well as methods of production and tableting.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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