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PRESERVATIVE SYSTEM FOR EMULSION-BASED THERAPEUTIC TOPICAL FORMULATIONS
专利权人:
Topaz Pharmaceuticals Inc.
发明人:
Spring, Nicholas,Delaney, Edward J.
申请号:
AU2016201858
公开号:
AU2016201858A1
申请日:
2016.03.24
申请国别(地区):
AU
年份:
2016
代理人:
摘要:
#$%^&*AU2016201858A120160421.pdf#####ABSTRACT A topical formulation that inhibits the growth of microorganisms comprises an effective amount of an insecticide dissolved in an oil phase comprising a water-miscible or water-soluble surface active agent, a suspending agent, and a 5 non-ionic surfactant, and an aqueous phase comprising one or more preservatives, where the aqueous phase is buffered to a specific pH. The overall antimicrobial efficacy in an emulsion formulation can be enhanced by buffering the aqueous phase of the emulsion to a pH at which the preservative system inhibits growth for a wider variety of microorganism types in the formulation relative to the equivalent formulation 10 in which the aqueous phase is not buffered.
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