Felicity Cutts,Jorge Fernandez De Castro,John V. Bennett,Beth Laube,Clyde Witham,Ana Maria Henao-Restrepo,Bernard Cohen,David Brown,John Dennis
申请号：
US13650535
公开号：
US08887713B2
申请日:
2012.10.12
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention provides a method of selecting a nebulizer device to be used to deliver a vaccine comprising selecting a nebulizer capable of producing a plurality of vaccine particles having the following particle droplet size distribution:(i) Dv10: 2.0+/−0.2 μm(ii) Dv50: 5.0+/−0.5 μm(iii) Dv90: 10.0+/−1.0 μm(iv) a mean mass aerodynamic diameter (MMAD) of 4.5 to 8.0 μmThis allows the selection of, for example, commercially available nebulizers, previously used for drug delivery, for vaccine delivery. This considerably reduces the work required to identify suitable nebulizers.Nebulizers identified by the methods of the invention are also claimed.
