The United States of America, as represented by the Secretary, Department of Health and Human Service;The University of Birmingham, of Edgbaston
发明人:
Jay A. Berzofsky,Jessica J. O'Konek,Masaki Terabe,Petr A. Illarionov,Gurdyal S. Besra,Jessica J. OKonek
申请号：
US14453829
公开号：
US09168291B2
申请日:
2014.08.07
申请国别(地区):
US
年份:
2015
代理人:
摘要：
β-mannosylceramides or salts or solvates thereof in a pharmaceutically acceptable carrier, for use as a Type I NKT cell agonist in conjunction with a therapeutically effective amount of α-galactosylceramide or a salt or a solvate thereof, and/or at least one or more T-cell co-stimulatory molecules, disclosed. Compositions comprising β-mannosylceramide, as well as methods of treatment of tumors are also provided.
