Chang Hwan Kim,Sung Kap Hong,Byung Sun Lee,Soo Young Kwak,Mi Ji Lee,In Young Choi,Se Chang Kwon
申请号：
US13638860
公开号：
US09186415B2
申请日:
2011.04.04
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to a long-acting human follicle-stimulating hormone formulation having improved in vivo duration and stability, comprising a human follicle-stimulating hormone conjugate that is prepared by covalently linking human follicle-stimulating hormone with an immunoglobulin Fc region via a non-peptidyl polymer, and a preparation method thereof. The long-acting human follicle-stimulating hormone formulation of the present invention maintains in vivo activity of human follicle-stimulating hormone at a relatively high level and remarkably increases the serum half-life thereof.
