Gregory J. LaRosa,Christopher Horvath,Walter Newman,S. Tarran Jones,Siobhan H. OBrien,Theresa OKeefe
申请号：
US13528407
公开号：
US08926971B2
申请日:
2012.06.20
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.
