A wire guide system and method of use are described. The wire guide system comprises a sheathing member, an elongate member, and a self-expandable expandable anchoring portion. The expandable anchoring portion is affixed to the distal end of the elongate member. Advancement of the wire guide system may be achieved by pre-loading the elongate member and the expandable anchoring portion into a lumen of the sheathing member. Upon reaching a target site within a body lumen, the sheathing member is proximally retracted so as to expose the expandable anchoring portion. Retraction of the sheathing member allows the expandable anchoring portion to radially self-expand and engage one or more walls of the body lumen so as to anchor the elongate wire in position. The elongate wire now provides a stabilized pathway for medical devices to be advanced thereover.
