Medical systems, devices and methods are disclosed for suturing a perforation in tissue, that may be employed endoscopically and/or laparoscopically, and that offer simple, reliable and controllable placement of sutures around a perforation for complete closure thereof. One embodiment of the medical system generally includes an endoscope, an endcap, an elongated side tube, a needle, a suture and a retrieval device. The endcap is fitted to a distal end of the endoscope. The elongated side tube defines a side channel and is connected to the endcap. The needle has a shaft and a needle tip detachably connected to a distal end of the shaft. The needle is sized to be translated through the side channel of the side tube. The suture is attached to the needle tip. The retrieval device is sized to be translated through a working channel of the endoscope and retrieve the needle tip.
