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NASAL SPRAY DEVICE
专利权人:
发明人:
申请号:
EP11779089.9
公开号:
EP2627386B1
申请日:
2011.10.12
申请国别(地区):
EP
年份:
2015
代理人:
摘要:
This invention relates to a nasal spray device (1) for the delivery of a pharmaceutical formulation to the nasal cavity in metered doses. The device comprises: a pressurised aerosol canister (3) including a vial (4) containing a pharmaceutical formulation comprising an active ingredient, a propellant and, optionally, a co- solvent, the aerosol canister further including a metering valve (6) having a valve stem (8) and an actuator (2) for the aerosol canister, the actuator including a stem block (11) having a receptacle into which the valve stem of metering valve of the aerosol canister is received and axially located and being displaceable relative to the vial of the aerosol canister to actuate the metering valve of the aerosol canister, a sump (15) extending below the receptacle, the stem block further defining a discharge orifice (19) for the pharmaceutical formulation and a transfer channel (13) through which a dispensed dose of the pharmaceutical formulation is able to pass from the sump to the discharge orifice. The actuator further comprises a delivery outlet (12) for the aerosol plume, the discharge orifice being arranged to direct the aerosol plume through the delivery outlet, and wherein the device is adapted to produce an aerosol plume for a dispensed dose having a spray force value no greater than 40 mN measured at a distance of 30 mm from the discharge orifice. Use of the term formulation encompasses both solution and suspension formulations.La présente invention concerne un dispositif de pulvérisation nasale (1) pour ladministration dune formulation pharmaceutique dans la cavité nasale en doses mesurées. Le dispositif comprend : une bouteille aérosol sous pression (3) comprenant un flacon (4) renfermant une formulation pharmaceutique comprenant un principe actif, un propulsif et, facultativement, un co-solvant. La bouteille aérosol comprend en outre une valve doseuse (6) ayant une tige de valve (8), et un actionneur (2) pour la bouteille aérosol, lactio
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