TINEL, Hanna,WUNDER, Frank,BECKER-PELSTER, Eva Maria,BUCHGRABER, Philipp,BUCHMULLER, Anja,ENGEL, Karen,GEIß, Volker,GOLLER, Andreas,HIMMEL, Herbert,KAST, Raimund,KNORR, Andreas,LANG, Dieter,REDLICH, G
申请号：
PE0008412016
公开号：
PE08422016A1
申请日:
2014.12.16
申请国别(地区):
PE
年份:
2016
代理人:
摘要：
Refers to piperidiniltetrahidroquinolinas substituted derivative compounds of formula (i) wherein R1, R2, R3 and R4 are as defined in the description.Preferred compounds are: [4 - (4 - dihidroisoquinolin - 2 (1H) - il) piperidin-1-yl] {6 - [(2-methoxyethyl) amino] pyridin-3-yl) methanone [4 - (7 - fluoro - 3.4 - dihidroisoquinolin - 2 (1H) - il) piperidin il] {- 1 - 6 - [(2-methoxyethyl) amino] pyridin-3-yl) methanone among others. It also refers to a process of Preparation and to a Pharmaceutical composition.These compounds are useful as alfa2c adrenergic Receptor Antagonists for the treatment of diabetic microangiopatias limbs, diabetic ulcers, Heart Failure, diabetic microvascular diabetic coronary heart diseaseSE REFIERE A COMPUESTOS DERIVADOS DE PIPERIDINILTETRAHIDROQUINOLINAS SUSTITUIDAS DE FORMULA (I) DONDE R1, R2, R3 Y R4 SON TAL COMO SE DEFINEN EN LA DESCRIPCION. SON COMPUESTOS PREFERIDOS: [4-(3,4-DIHIDROISOQUINOLIN-2(1H)-IL)PIPERIDIN-1-IL]{6-[(2-METOXIETIL)AMINO]PIRIDIN-3-IL}METANONA [4-(7-FLUORO-3,4-DIHIDROISOQUINOLIN-2(1H)-IL)PIPERIDIN-1-IL]{6-[(2-METOXIETIL)AMINO]PIRIDIN-3-IL}METANONA ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCESO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR ADRENERGICO alfa2C SIENDO UTILES PARA EL TRATAMIENTO DE MICROANGIOPATIAS DIABETICAS, ULCERAS DIABETICAS DE LAS EXTREMIDADES, FALLA CARDIACA DIABETICA, TRASTORNOS CARDIACOS MICROVASCULARES CORONARIOS DIABETICOS
