作為離子通道調節劑之稠合雜環化合物农业专利-农业学术服务平台

发明人:: CORKEY, BRITTON,柯奇　布莱顿,柯奇　布萊頓,ELZEIN, ELFATIH,艾尔连　艾尔法堤,艾爾連　艾爾法堤,JIANG, ROBERT,蒋海波,蔣海波,KALLA, RAO,卡拉　罗欧,卡拉　羅歐,KOBAYASHI, TETSUYA,小林彻也,小林徹也,KOLTUN, DMITRY,考登　丹米堤,LI, XIAOFEN,李晓芬,李曉芬,NOTTE, GREGOR,柯奇布莱顿,柯奇布萊頓,艾尔连艾尔法堤,艾爾連艾爾法堤,卡拉罗欧,卡拉羅歐,考登丹米堤

摘要：: The present invention relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I:wherein W1, W2, W3, R1, Q, X1, X2and X3are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.本發明係有關鈉通道抑制劑之化合物且有關其治療各種病況之用途，包括心血管疾病及糖尿病，亦有關製備該等化合物之方法及用途且有關含有該等化合物之醫藥組成物。特定具體實施態樣中，化合物結構係表示為式I：其中W1、W2、W3、R1、Q、X1、X2及X3係如此處所述。