Stable formulations of programmed death receptor 1 (PD-1) antibodies and methods of use thereof

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专利权人:

Merck Sharp & Dohme Corp.

发明人:

Sharma, Manoj K.,Benjamin, Wendy,Mittal, Sarita,Basarkar, Ashwin,Narasimhan, Chakravarthy Nachu,Kashi, Ramesh S.,Shameem, Mohammed,Bhattacharya, Soumendu,Forrest Jr., William P.,Krishnamachari, Yogita

申请号：

AU2018263862

公开号：

AU2018263862A1

申请日:

2018.05.01

申请国别(地区):

AU

年份:

2019

代理人:

摘要：

The invention relates to stable formulations of antibodies against human programmed death receptor PD-1, or antigen binding fragments thereof. In some embodiments the formulations of the invention comprise between 5-200 mg/mL anti- PD-1 antibody, or antigen binding fragment thereof. The invention further provides methods for treating various cancers with stable formulations of the invention. In some embodiments of the methods of the invention, the formulations are administered to a subject by intravenous or subcutaneous administration.

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中国工程科技知识中心

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http://www.ckcest.cn/home/