UNIVERSIDADE FEDERAL DE MINAS GERAIS- UFMG;FUNDAÇAO DE AMPARO A PESQUISA DO ESTADO DE MINAS GERAIS- FAPEMIG
发明人:
Frederic JEAN GEORGES FREZARD,Erly GUILHERME AZEVEDO,Raul RIO BIBEIRO,Cynthia PERES DEMICHELI,Sydnei MAGNO DA SILVA,Simone APARECIDA REZENDE
申请号：
US14384155
公开号：
US20150306035A1
申请日:
2013.03.11
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to a pharmaceutical composition for treating visceral leishmaniasis, characterized in that it comprises the association of conventional liposomes and prolonged-circulation liposomes with a leishmanicidal-drug delivery system. Said composition may be used in the preparation of a medicinal product for treating leishmaniasis and may be administered intramuscularly, subcutaneously, intraperitoneally or intravenously. The use of this system enables the drug efficiently to reach all sites infected by the parasite, the pegylated liposomes promoting more effective targeting of the leishmanicidal drugs on the bone marrow and spleen, whilst the conventional liposomes contribute to the targeting of the drug on the liver.
