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COMPOSE DE PROLINEAMIDE SUBSTITUE PAR UN PHENYLDIFLUOROMETHYLE
专利权人:
ASTELLAS PHARMA INC.
发明人:
NAKAJIMA, YUTAKA,IMADA, SUNAO,YAMAMOTO, ERIKO,TSUCHIYA, KAZUYUKI,HARAYAMA, YU,MATSUMOTO, SHUNICHIRO
申请号:
CA3050224
公开号:
CA3050224A1
申请日:
2018.01.23
申请国别(地区):
CA
年份:
2018
代理人:
摘要:
[Problem] To provide a compound useful as a cathepsin S inhibitor. [Solution] The present inventors have studied on a compound which has a cathepsin S-inhibiting activity and can be used as an active ingredient for a pharmaceutical composition for preventing and/or treating an autoimmune disease such as systemic lupus erythematosus (SLE) and lupus nephritis, an allergy, or organ, bone marrow or tissue graft rejection. As a result, it has been confirmed that a phenyldifluoromethyl-substituted prolineamide compound according to the present invention has a cathepsin S-inhibiting activity. This confirmation leads to the accomplishment of the present invention. The phenyldifluoromethyl-substituted prolineamide compound according to the present invention has a cathepsin S-inhibiting activity, and can be used as a prophylactic and/or therapeutic agent for an autoimmune disease such as SLE and nephritis, an allergy, or organ, bone marrow or tissue graft rejection.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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