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Glass-stabilised biological materials and syringe
专利权人:
BRUCE ROSER
发明人:
BRUCE ROSER
申请号:
GB201201426
公开号:
GB2498774A
申请日:
2012.01.27
申请国别(地区):
GB
年份:
2013
代理人:
摘要:
A syringe for the injection of drugs or vaccines is described in which pharmaceuticals are stabilised by drying with an agent that forms a soluble glass which coats the internal surfaces of the voids in a compliant porous matrix 5. The porous matrix is located inside the barrel 1 of a syringe and the pharmaceuticals are solubilised for injection by the aspiration of a solvent, usually water or saline. The active substance is delivered to the patient by the normal injection process of fully depressing the plunger of the syringe which compresses the compliant porous matrix to completely expel the solubilised product into the injected liquid and thereby into the patient. The glass forming compound may be a sugar, a carbohydrate or an amino acid. Preferred compounds are trehalose, monosodium glutamate and monosodium aspartate. Also disclosed are: - A method of storing/transporting a biological agent stabilized in a glassy substance; - A method of preparing a pharmaceutical for injection by dissolving the glassy substance and dissolving or dispersing the active ingredient; - A syringe defining a spongy body having a glassy material deposited on the pores thereof, whereby a solvent can pass through and dissolve the glassy material.
来源网站:
中国工程科技知识中心
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