VERKMAN, ALAN S.,PHUAN, PUAY-WAH,KURTH, MARK J.,KNAPP, JOHN
申请号：
CA2754237
公开号：
CA2754237A1
申请日:
2011.09.29
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The present disclosure provides pharmaceutical compositions, pharmaceuticalpreparations and methods for increasing activity of a mutant cystic fibrosistransmembraneconductance regulator protein (mutant-CFTR). The pharmaceutical compositions,pharmaceutical preparations and methods are useful for the study and treatmentof disordersassociated with mutant-CFTR, such as cystic fibrosis. The pharmaceuticalcompositions andpharmaceutical preparations may include one or more cyanoquinoline-containingcompoundsof the embodiments, or an analog or derivative thereof.
