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PolyAnionic Delivery of Nucleic Acids
专利权人:
Inc.;Translate Bio
发明人:
Michael Heartlein,Frank DeRosa,Shrirang Karve
申请号:
US16491475
公开号:
US20200017440A1
申请日:
2018.03.07
申请国别(地区):
US
年份:
2020
代理人:
摘要:
Disclosed are dendritic anionic lipids which are compounds of Formula (I): wherein R and R1 are non-polar groups, L is a linking moiety, and Dm is a dendritic moiety of m generations, each as defined herein. These dendritic anionic lipids are useful for delivery and expression of m RNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.
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