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(AZA)INDOLE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES
专利权人:
KISSEI PHARMACEUTICAL CO.; LTD.
发明人:
KAZUO SHIMIZU,YASUSHI TAKIGAWA,HIDEKI FUJIKURA,MASATO IIZUKA,MASAHIRO HIRATOCHI,NORIHIKO KIKUCHI
申请号:
PT08740190
公开号:
PT2133332E
申请日:
2008.04.10
申请国别(地区):
PT
年份:
2013
代理人:
摘要:
The present invention provides compounds useful as agents for the prevention or treatment of a disease associated with abnormal serum uric acid level which has a uricosuric activity or the like. The present invention relates to (aza)indole derivatives represented by the following general formula (I) having xanthine oxidase inhibitory activities and useful as agents for the prevention or treatment of a disease associated with abnormality of serum uric acid level, prodrugs thereof, or salts thereof. In the formula (I), T represents nitro or cyano and the like ring J represents aryl or heteroaryl and the like Q represents carboxy or 5-tetazolyl and the like Y represents H, OH, NH 2 , halogen, nitro, alkyl, alkoxy and the like X 1 , X 2 and X 3 independently represent CR 2 or N R 1 and R 2 independently represent halogen, cyano, haloalkyl, A-D-E-G, -N(-D-E-G) 2 and the like, in the formula, A represents a single bond, O, S and the like D and G independently represent optionally substituted alkylene, cycloalkylene, heterocycloalkylene, arylene, heteroarylene and the like E represents a single bond, O, S, COO, SO 2 and the like.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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