Donald Rao,Zhaohui Wang,John J. Nemunaitis,Neil Senzer,Bert W. OMalley,David Lonard
申请号：
US13851464
公开号：
US20130259925A1
申请日:
2013.03.27
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention includes compositions and methods of making and using an expression vector comprising a promoter and a nucleic acid insert operably linked to the promoter, wherein the insert encodes one or more short hairpin RNAs (shRNA) capable of inhibiting an expression of a SRC-3 gene via RNA interference, wherein the one or more shRNA comprise a bifunctional RNA molecule that activates a cleavage-dependent and a cleavage-independent RNA-induced silencing complex for reducing the expression level of the SRC-3.
