A method for imaging is presented. The method includes receiving a first image data set and at least one other image data set. Further the method includes adaptively selecting corresponding regions of interest in each of the first image data set and the at least one other image data set based upon apriori information associated with each of the first image data set and the at least one other image data set. Additionally, the method includes selecting a customized registration method based upon the selected regions of interest and the apriori information corresponding to the selected regions of interest. The method also includes registering each of the corresponding selected regions of interest from the first image data set and the at least one other image data set employing the selected registration method.