An isolator system includes a first isolator forming a first workspace being hermetically sealed from an ambient environment, a second isolator forming a second workspace being hermetically sealed from the ambient environment, and a pass box provided between the first isolator and the second isolator and forming a transport space enabled to communicate the first workspace and the second workspace while maintaining hermeticity, wherein the pass box has a tray on which an article used in work is mounted, and a moving mechanism configured to enable movement of the tray toward directions to both sides of the first isolator and the second isolator, the tray has a first end on the first isolator side located in the first workspace when moved to the first isolator side, and a second end on the second isolator side located in the second workspace when moved to the second isolator side.
